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STAT3 Rabbit Monoclonal Antibody
Key facts:
Catalog NO:TR8010
Source :Rabbit
Type:Monoclonal
Application:WB,IHC-P,IF-P,IF-F,IF-ICC,ELISA
Reactivity:Human,Mouse,Rat
Isotype:IgG, Kappa
MW(KDa):88kDa
Alternative Names:STAT3;APRF;Signal transducer and activator of transcription 3;Acute-phase response factor
Specifications:
Specificity

Endogenous

 

Storage

Store at -20°C. Stable for one year from the date of shipment.

 

Concentration

1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.

 

Dilutions

IHC-P 1:100-1:500, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000

(Optimal dilutions should be determined by the end user)
Background:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
Applications:
Western  Blot                                

Western blot analysis of lysates from MCF7 cells, using STAT3 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody was used to detect the antibody.
Immunohistochemistry

Single-cell and spatial transcriptomic analyses revealing tumor microenvironment remodeling after neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Mol Cancer 24, 111 (2025).
IHC-P, human Non-small cell lung cancer (NSCLC) tissue, primary antibodies against STAT3 (RM8010), STAT5 (RM0478), IL-2 (BD-PE0366), Beta Catenin (RM1224), TGF-beta (RM3267), E2F1 (RM4981).
Contact information:
Company:BEI JING TDY BIOTECH CO.,LTD.
Orders:TDYbiotech@163.com
Website:http://www.tdybio.com
Telephone:010-80117836
Address:Zhen Xin Road 36.Changping Distict,Beijing
Reactivity: H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep Pg-Pig
Applications: WB-Western blot IHC-Immunochemistry IF-Immunofluorescence IP-Immunoprecipitation ChIP-Chormatin Immunoprecipitation
Please note: All products are"FOR RESEARCH USE ONLY.NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES".