PARP-1 Rabbit pAb

Key facts:

Catalog NO:	TT6210
Source :	Rabbit
Type:	Polyclonal
Application:	WB,IHC,IF
Reactivity:	H,M,R
Isotype:	IgG
MW(KDa):	113
Alternative Names:	Poly [ADP-ribose] polymerase 1 ; PARP-1 ; ADP-ribosyltransferase diphtheria toxin-like 1 ; ARTD1 ; ADP-ribosyltransferase 1 ; ADPRT 1 ; Poly[ADP-ribose] synthase 1 ;

Specifications:

Source

Synthesized peptide derived from human PARP-1. AA range: 410-460

Specificity

This antibody detects endogenous levels of human PARP-1

Storage

Store at -20°C. Stable for one year from the date of shipment.

Concentration

1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.

Dilutions

WB 1:500-2,000; IHC 1:50-200; IF 1:50-200

(Optimal dilutions should be determined by the end user)

Background:

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Applications:

Western Blot	Zhou, Li, et al. "Coptisine induces apoptosis in human hepatoma cellsthrough activating 67-kDa laminin receptor/cGMP signaling." Frontiers inpharmacology 9 (2018).
Western Blot	Yao, Chong, et al. "Crocin induces autophagic apoptosis in hepatocellularcarcinoma by inhibiting Akt/mTOR activity." OncoTargets and therapy 11(2018): 2017.
Immunohistochemistry	Immunohistochemical analysis of para?n-embedded human brain

Contact information:

Company:	BEI JING TDY BIOTECH CO.,LTD.
Orders:	TDYbiotech@163.com
Website:	http://www.tdybio.com
Telephone:	010-80117836
Address:	Zhen Xin Road 36.Changping Distict,Beijing

Reactivity: H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep Pg-Pig

Applications: WB-Western blot IHC-Immunochemistry IF-Immunofluorescence IP-Immunoprecipitation ChIP-Chormatin Immunoprecipitation

Please note: All products are"FOR RESEARCH USE ONLY.NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES".