| Cat#： TM4305 | Source#： Mouse | Type#： Monoclonal | |
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| Applications: WB,IF,ELISA,IHC |
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Reactivity: H,M,R |
| MW.(KDa): 44 |
Isotype: IgG2b,kappa |
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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. |
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| Western Blot |
Whole cell lysates of K562 were separated by 10% SDS-PAGE, and the membrane was blotted with anti-TGF β1 antibody.
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| Source |
Synthesized peptide derived from human TGF β1 AA range: 300-390 |
| Specificity |
This antibody detects endogenous levels of TGF β1 protein. |
| Storage |
Store at -20°C. Stable for one year from the date of shipment. |
| Concentration |
1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Dilutions |
WB 1:500-2,000; IHC 1:200-1000; IF 1:100-500; ELISA 1:1,000 -5,000
(Optimal dilutions should be determined by the end user)
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| Transforming growth factor beta-1 ; TGF-beta-1 ; [Cleaved into: Latency-associated peptide ; LAP |
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| Size: |
50μL ￥1000
100μL ￥1800 |
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| New Product: |
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| 直接下单: |
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立即下单
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