| Cat#： TM4036 | Source#： Mouse | Type#： Monoclonal | |
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| Applications: WB,IHC,IF,ELISA |
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Reactivity: H |
| MW.(KDa): 72kD (Calculated) 110kD (Observed) |
Isotype: IgG1,kappa |
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function:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis., |
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| Western Blot |
Various whole cell lysates were separated by 15% SDS-PAGE, and the membrane was blotted with anti-CD146 antibody.
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| Immunohistochemistry |
Human placenta tissue was stained with Anti-CD146 Antibody
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| Source |
Synthesized peptide derived from human CD146 AA range: 500-600 |
| Specificity |
This antibody detects endogenous levels of CD146 protein. |
| Storage |
Store at -20°C. Stable for one year from the date of shipment. |
| Concentration |
1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Dilutions |
WB 1:500-2,000; IHC 1:200-1000; IF 1:100-500; ELISA 1:1,000-5,000
(Optimal dilutions should be determined by the end user)
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| Cell surface glycoprotein MUC18 ; Cell surface glycoprotein P1H12 ; Melanoma cell adhesion molecule ; Melanoma-associated antigen A32 ; Melanoma-associated antigen MUC18 ; S-endo 1 endothelial-associated antigen ; CD antigen CD146 ; |
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| Size: |
50μL ￥1000
100μL ￥1800 |
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| New Product: |
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| 直接下单: |
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立即下单
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