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PCSK9 (2G2) Rabbit Monoclonal Antibody
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Proprotein convertase subtilisin/kexin type 9;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;P
 
Cat#: TR9330   |   Source#: Rabbit   |   Type#: Monoclonal   |
Applications: WB,IF-P,IF-F,IF-ICC,IP,ELISA   Reactivity: Human,Rat
MW.(KDa): 65kDa(mature form),80kDa(precursor) Isotype: IgG, Kappa
cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,
Applications Specifications Alternative Names
 
  Size:
50μL ¥1300
100μL ¥2300

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