| Cat#： TR8648 | Source#： Rabbit | Type#： Monoclonal | |
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| Applications: WB,IHC-P,IF-P,IF-F,IF-ICC,IP,ELISA |
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Reactivity: Human |
| MW.(KDa): 270kDa |
Isotype: IgG, Kappa |
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| This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian |
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| BRCA1;RNF53;Breast cancer type 1 susceptibility protein;RING finger protein 53 |
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| Size: |
50μL ￥1300
100μL ￥2300 |
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| New Product: |
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| 直接下单: |
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立即下单
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