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| NLRP3 Rabbit pAb |
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| NLRP3 ; C1orf7 ; CIAS1 ; NALP3 ; PYPAF1 ; NACHT, LRR and PYD domains-containing protein 3 ; Angiotensin/vasopressin re |
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| Cat#： TT5382 | Source#： Rabbit | Type#： Polyclonal | |
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| Applications: WB,IHC,IF,ELISA |
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Reactivity: H,M,R |
| MW.(KDa): 115 |
Isotype: IgG |
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| This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. |
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| Source |
The antiserum was produced against synthesized peptide derived from the Internal region of human NLRP3. AA range:511-560
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| Specificity |
Cryopyrin Polyclonal Antibody detects endogenous levels of Cryopyrin protein.
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| Storage |
Store at -20°C. Stable for one year from the date of shipment.
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| Concentration |
1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
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| Dilutions |
WB 1:500-2,000; IHC 1:100-300; IF 1:50-200; ELISA 1:20,000
(Optimal dilutions should be determined by the end user)
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| NLRP3 ; C1orf7 ; CIAS1 ; NALP3 ; PYPAF1 ; NACHT, LRR and PYD domains-containing protein 3 ; Angiotensin/vasopressin receptor AII/AVP-like ; Caterpiller protein 1.1CLR1.1 ; Cold autoinflammatory syndrome 1 protein ; Cryopyrin ; PYRIN-containing APAF1-like protein 1 |
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| Size: |
50μL ￥1000
100μL ￥1800 |
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| New Product: |
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