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| FoxO1A (Acetyl Lys245) Rabbit pAb |
📄 生成PDF
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| Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma |
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| Cat#： TDYK0110 | Source#： Rabbit | Type#： Polyclonal | |
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| Applications: WB,ELISA |
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Reactivity: H,M,R |
| MW.(KDa): 72 |
Isotype: IgG |
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| disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220];
also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3; translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.,function:Transcription factor.,PTM:Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNAbinding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Interacts with LRPPRC.,tissue
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| Western Blot |
Western Blot analysis of HEK 293 cells, cell treated or untreated by TSA 400nM 24h. Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS23920 was diluted at 1:10000
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| Source |
Synthesized peptide derived from human FoxO1A (Acetyl Lys245)
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| Specificity |
This Polyclonal Antibody detects endogenous levels of Human,Mouse,Rat FoxO1A (Acetyl Lys245)
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| Storage |
Store at -20°C. Stable for one year from the date of shipment.
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| Concentration |
1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
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| Dilutions |
WB 1:1,000-2,000; ELISA 1:5,000-20,000
(Optimal dilutions should be determined by the end user)
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| Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma |
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| Size: |
50μL ￥1000
100μL ￥1800 |
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| New Product: |
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| 直接下单: |
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立即下单
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